The Technical Competencies Guide to Working with First Nations Clients provides a First Nations context for the updated Technical Competencies in the Canadian Centre on Substance Abuse’s (CCSA) Competencies for Canada’s Substance Abuse Workforce,1 and reflects cultural principles derived from Indigenous knowledge, including spiritual and cultural teachings from an Indigenous world view. This work is informed by Honouring Our Strengths: A Renewed Framework to Address Substance Abuse Issues among First Nations People in Canada (HOS), which engaged “a variety of interrelated knowledge gathering and engagement activities, such as regional needs assessments, research papers and regional focus groups.”